Targeting intrinsically disordered peptides in oncology

Figure 1. Schematic representation of the research workflow.
Figure 2. The figure illustrates the different peptide derivatives with their measured binding affinity (KD values) for eIF4E and based on which they are classified into separate binder class. The peptides are shown in cartoon, eIF4E protein in surface and non-natural Aib amino acid in stick representations. A modelled complex of the best binder peptide with eIF4E is also depicted.

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